Gas-filled lipid spheres for use in diagnostic and therapeutic applications
AssigneeImaRx Pharmaceutical Corp.
InventorsEvan C. Unger, Terry Matsunaga, David Yellowhair
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Abstract
A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.
Claims102
A gas filled liposome comprising a substantially insoluble gas in combination with a soluble gas, wherein said liposome comprises at least one phosphatidylcholine, at least one phosphatidylethanolamine, and at least one phosphatidic acid, wherein said phosphatidylcholine is selected from the group consisting of dioleoylphosphatidylcholine, dimystoylphosphatidylcholine, dipalmitoylphosphatidylcholine, and distearoyl-phosphatidylcholine, said phosphatidylethanolamine is selected from the group consisting of dipalmitoylphosphatidylethanolamine, dioleoyl-phosphatidylethanolamine and N-succinyl-dioleoyl-phosphatidylethanolamine, and said phosphatidic acid is dipalmatoylphosphatidic acid.
A gas-filled lipid sphere comprising a substantially insoluble gas in combination with a soluble gas, wherein said lipid comprises at least one phosphatidylcholine, at least one phosphatidylethanolamine, and at least one phosphatidic acid, wherein said phosphatidlicholine is selected from the group consisting of dioleoylphosphatidylcholine, dimyristoylphosphatidylcholine, dipalmitoylphosphatidylcholine, and distearoyl-phosphatidylcholine, said phosphatidylethanolamine is selected from the group consisting of dipalmitoylphosphatidylethanolamine, dioleoyl-phosphatidylethanolamine, and N-succinyl-dioleoyl-phosphatidylethanolamine, and said phosphatidic acid is dipalmatoylphosphatidic acid.
Dependencies are inferred from the claim text.