Adhesive medical composition with sustained medicament releasbility and process for preparing same
AssigneeAlcare Co., Ltd.
InventorTakabumi Kubo
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a blending medical composition with a sustained medicament releasability, which can reduce the amount of medicament required to be contained in the composition, and can control the amount of medicament to be released according to a degree of moisture present at a moist application site. The present composition includes a medicament-containing hydrophilic composition including a water-soluble or water-dispersible hydrophilic composition and a medicament, dispersed and blended into a binding composition capable of retaining the medicament-containing hydrophilic composition.
Claims18
An adhesive composition with a sustained medicament releasability, comprised of a medicament, a hydrophilic composition, and a binding composition capable of retaining the hydrophilic composition, said hydrophilic composition being soluble in water, humor and exudate, and being selected from the group consisting of natural hydrophilic compositions, semi-synthetic hydrophilic compositions and synthetic hydrophilic compositions and mixtures thereof, said medicament being dispersed and blended into said hydrophilic composition to form a medicament-containing hydrophilic composition, and particles of said medicament-containing hydrophilic composition being dispersed in said binding composition, wherein a portion of said medicament-containing hydrophilic composition particles is capable of being exposed to an outside surface of said binding composition by dissolution, separation or decomposition of said medicament-containing hydrophilic composition particles by absorption of a water-containing liquid, to release said medicament from said portion of said medicament-containing hydrophilic composition particles.
A process for preparing an adhesive composition with a sustained medicament releasability, comprising the steps of:
- (a) uniformly mixing a hydrophilic composition and a medicament to form a medicament-containing hydrophilic composition so that the medicament is physically enclosed into the hydrophilic composition then grinding the medicament-containing hydrophilic composition into particles;
- and then
- (b) uniformly mixing the particles of the medicament-containing hydrophilic composition with a moisture-soluble or a water-soluble binder so that the particles of the medicament-containing hydrophilic composition are dispersed in the binder.
A process for applying an adhesive composition with a sustained medicament releasability to a living body, wherein the process includes the following steps:
- (a) forming the adhesive medical composition with a sustained medicament releasability by uniformly mixing a hydrophilic composition and a medicament in a moist condition to form a hydrophilic composition with the medicament physically enclosed therein, followed by driving and grinding the hydrophilic composition with the medicament physically enclosed therein into particles, followed by uniformly mixing the particles of the hydrophilic composition with the medicament physically enclosed therein with a moisture or a water-soluble binder so that the medicament-containing hydrophilic composition particles are dispersed in the binder to form the adhesive composition with a sustained medicament releasability;
- (b) applying the adhesive composition with a sustained medicament releasability to a portion of a living body in contact with moisture;
- and,
- (c) leaving the adhesive composition with a sustained medicament releasability in contact with the living body for a sufficient amount of time to absorb at least some moisture from the living body and to release an amount of the medicament in accordance with an amount of the moisture absorbed.
An adhesive composition with a sustained medicament releasability, comprising:
- a hydrophilic composition component containing a medicament, and
- an adhesive composition component selected from a group consisting of a hydrophobic pressure sensitive tackifier, a hydrophilic pressure sensitive tackifier, and a mixed pressure sensitive tackifier of hydrophobic ingredients and hydrophilic ingredients,
- wherein the adhesive composition with a sustained medicament releasability is made by a process wherein the medicament and the hydrophilic composition components are mixed in a moist condition to form an integrated mixture, then the integrated mixture is dried and then ground to form a powder, and then the powder is uniformly dispersed in the adhesive composition component, the medicament being physically enclosed in the hydrophilic composition component.
An adhesive composition with a sustained medicament releasability, comprising:
- a hydrophilic composition component soluble in water, humor and exudate, said hydrophilic composition component being selected from the group consisting of natural hydrophilic compositions, semi-synthetic hydrophilic compositions and synthetic hydrophilic compositions and mixtures thereof, and said hydrophilic composition component containing a medicament, and
- an adhesive composition component selected from the group consisting of a hydrophobic pressure sensitive tackifier, a hydrophilic pressure sensitive tackifier, and a mixed pressure sensitive tackifier of hydrophobic ingredients and hydrophilic ingredients,
- wherein the adhesive composition with a sustained medicament releasability is made by a process comprising the steps of:
- (a) homogeneously mixing fine powders of the hydrophilic composition component and the medicament, then admixing the mixture of the hydrophilic composition component and the medicament with a moisture soluble binder or a water-soluble binder to obtain an integrated mixture, and
- (b) uniformly mixing the integrated mixture into the binding composition component.
Dependencies are inferred from the claim text.