Vaccines

An immunogenic composition comprising an antigen and/or antigenic composition, QS21, 3-De-O-acylated monophosphoryl lipid A (3D-MPL) and an oil in water emulsion wherein the oil in water emulsion comprises a metabolizable oil, alpha tocopherol and TWEEN 80 (polyoxyethelene sorbitan monooleate) wherein said antigen and/or antigenic composition is selected from the group consisting of Herpes Simplex Virus type 1, Herpes Simplex Virus type 2, Human cytomegalovirus, Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis E, Respiratory Syncytial Virus, Human papilloma Virus, Influenza Virus, Salmonella, Neisseria, Borrelia, Chlamydia, Bordetella, Plasmodium and Toxoplasma.

An immunogenic composition comprising an antigen and/or antigenic composition, QS21, 3-De-O-acylated monophosphoryl lipid A (3D-MPL) and an oil in water emulsion wherein the oil in water emulsion comprises a metabolizable oil, alpha tocopherol and TWEEN 80 (polyoxyethelene sorbitan monooleate) wherein the antigen and/or antigenic composition is a tumor antigen.

An immunogenic composition comprising an antigen and/or antigenic composition, QS21, 3-De-O-acylated monophosphoryl lipid A (3D-MPL) and an oil in water emulsion wherein the oil in water emulsion comprises a metabolizable oil, alpha tocopherol and TWEEN 80 (polyoxyethelene sorbitan monooleate) wherein said antigen and/or antigenic composition is selected from the group consisting of Human Immunodeficiency Virus and Feline Immunodeficiency Virus.