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US 6,146,628 AGranted
Biotherapeutic agents comprising recombinant PAP and PAP mutants
AssigneesRegents of the University of Minnesota and Rutgers, The State University of New Jersey
InventorsFatih M. Uckun, Nilgun E. Tumer
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Abstract
Biotherapeutic agents are provided which comprise recombinant PAP or a biologically equivalent variant or mutant thereof, linked to a targeting moiety which are effective for the treatment of certain human diseases. The invention further provides a process for producing the biotherapeutic agents as well as a method which utilizes the disclosed biotherapeutic agents to systemically treat cancer patients.
Claims12
A fusion protein comprising:
- mutant Pokeweed Antiviral Protein (PAP) having an amino acid substitution at residue 75, 97, or 176;
- and a targeting moiety that binds a cell surface receptor.
An immunoconjugate comprising:
- mutant Pokeweed Antiviral Protein (PAP) having an amino acid substitution at residue 75, 97, or 176;
- and a targeting moiety that binds a cell surface receptor.
Dependencies are inferred from the claim text.