Use of certain anionic amino acid based surfactants to enhance antimicrobial effectiveness of topically administrable pharmaceutical compositions
AssigneeAlcon Laboratories, Inc.
InventorsErnesto J. Castillo, Steven Howard Gerson, Wesley Wehsin Han
Life of this patent
Estimating the term…
Abstract
Anionic amino acid based surfactants are used to enhance antimicrobial effectiveness in topically administrable pharmaceutical compositions containing at least one active ingredient, a cationic preservative and an anionic polyelectrolyte, such as carboxyvinyl polymers, xanthan gum, polystyrene sulfonic acid polymers and cationic exchange resins.
Claims18
A method of improving or enhancing the antimicrobial efficacy of a topically administrable pharmaceutical composition comprising a cationic antimicrobial, an anionic polyelectrolyte and an active ingredient, wherein the method comprises adding to the composition an antimicrobial-enhancing amount of an anionic amino acid based surfactant of the formula:
- ##STR4## wherein:
- R=C.sub.8 -C.sub.24 saturated or unsaturated hydrocarbon;
- Y=H, (CH.sub.2).sub.4 NH.sub.2 or (CH.sub.2).sub.3 NHC(NH.sub.2).dbd.N.sup.+ H.sub.2 ;
- and
- M.sup.+ =H or a pharmaceutically acceptable salt.
A topically administrable pharmaceutical composition comprising a cationic antimicrobial, an anionic polyelectrolyte, an active ingredient, and an antimicrobial-enhancing amount of an anionic amino acid based surfactant of the formula:
- ##STR5## wherein:
- R=C.sub.8 -C.sub.24 saturated or unsaturated hydrocarbon;
- Y=H, (CH.sub.2).sub.4 NH.sub.2 or (CH.sub.2).sub.3 NHC(NH.sub.2).dbd.N.sup.+ H.sub.2 ;
- and
- M.sup.+ =H or a pharmaceutically acceptable salt.
Dependencies are inferred from the claim text.