Device for incorporation and release of biologically active agents
AssigneeIsoTis N.V.
InventorsEugenia Ribeiro de Sousa Fidalgo Leitao, Joost Dick De Bruijn, Hai-Bo Wen, Klaas De Groot
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Abstract
The invention provides an implantable device coated with a layer of calcium phosphate and optionally one or more biologically active substances such as growth factors, lipids, (lipo)polysaccharides, hormones, proteins, antibiotics or cytostatics. The device can be obtained by a nanotechnology process comprising subjecting a substrate to a surface treatment until a surface roughness with an average peak distance (Ra value) between 10 and 1,000 nm and subjecting the roughened surface to precipitation of calcium phosphate from a solution containing calcium and phosphate ions with optional coprecipitation of the biologically active substance.
Claims10
An implantable device comprising a material having a precipitate enhancing roughened surface, before coating with an average peak distance between 10 nm and 1,000 nm and having an average depth, wherein the roughened surface is coated in vitro with a layer of a precipitate comprising calcium ions, phosphate ions, and an organic biologically active agent wherein at least a portion of the layer has a thickness greater than the average depth of the roughened surface.
Dependencies are inferred from the claim text.