Process for the preparation of 1,3-dicarbonyl compounds
AssigneeEastman Chemical Company
InventorsNeil W. Boaz, M. Todd Coleman
Life of this patent
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Abstract
The condensation reaction of a ketone with either an ester or a carbonate to form, respectively, a 1,3-diketone or a .beta.-ketoester often affords poor results under the standard condensation reaction conditions. High yields and high purities of the desired product can be obtained by performing the reaction using an alkoxide base in DMSO as the sole solvent.
Claims21
A process for preparing a 1,3-dicarbonyl compound comprising the step of reacting a ketone having an acidic proton at the .alpha.-position with an ester of the general formula (I):
- ##STR11## where R and R' are, independently, a substituted or unsubstituted C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.8 cycloalkyl, heterocycloalkyl, aryl or heteroaryl group in the presence of an alkoxide base in DMSO as the sole solvent.
A process for preparing a 1,3-dicarbonyl compound comprising the step of reacting a ketone having an acidic proton at the .alpha.-position with a carbonate of the general formula (II):
- ##STR12## where R" and R'" are, independently, a substituted or unsubstituted C.sub.1 -C.sub.10 alkyl, C.sub.3 -C.sub.8 cycloalkyl, heterocycloalkyl, aromatic or heteroaromatic group in the presence of an alkoxide base in DMSO as the sole solvent.
Dependencies are inferred from the claim text.