Process for the preparation of optically active methadones in high enantiomeric purity
AssigneeSalford Ultrafine Chemicals and Research Limited
InventorsFeodor Scheinmann, Jonathan David Hull, Nicholas John Turner
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Abstract
A method of preparing optically active methadones comprises an enzymatic process for the resolution of 1-dialkyl-amino-2-propanol and conversion of the enantiomers to the optically active methadones in high enantiomeric purity.
Claims11
A method of preparing optically active methadones comprising the enzymatic resolution of 1-dimethyl-amino-2-propanol in the presence of ester so as to produce S-1-dimethylamino-2-propanol and R-ester of 1-dimethylamino-2-propanol, the method further comprising the conversion of one or both of the S-1-dimethylamino-2-propanol and/or R-ester of 1-dimethylamino-2-propanol to yield S(+)-methadone and/or R(-)-methadone respectively.
Dependencies are inferred from the claim text.