Synthesis and use of .alpha.-ketoamide derivatives and arrays

A non-peptidyl compound represented by the formula:

• ##STR19## wherein A is independently selected from the group consisting of alkyl groups, carbocyclic groups, and aryl groups;
• B and C are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups;
• Y is a linker moiety selected from the group consisting of ethylbenzene-2',4-diyl and toluene-1',4-diyl;
• and
• D is selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, aryl groups, C(X)--Z--W, wherein X is O or S, Z is a single bond or NR;
• and R and W are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups.

A non-peptidyl compound represented by the formula:

• ##STR20## wherein A is independently selected from the group consisting of alkyl groups, carbocyclic groups, and aryl groups;
• B and C are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups;
• Y is a linker moiety selected from the group consisting of divalent alkyl groups, carbocyclic groups, and aryl groups;
• and
• D is the triazolinyl moiety:
• ##STR21## wherein X and Z are each independently selected from the group consisting of unsubstituted, monosubstituted, and disubstituted amino groups, thioalkyl groups, thioaryl groups, alkoxy groups, aryloxy groups, halogens, alkyl groups, carbocyclic groups, and aryl groups.

A non-peptidyl compound represented by the formula:

• ##STR22## wherein A is independently selected from the group consisting of alkyl groups, carbocyclic groups, and aryl groups;
• B and C are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups;
• Y is a linker moiety selected from the group consisting of divalent alkyl groups, carbocyclic groups, and aryl groups;
• and
• D is the oxazolinyl moiety:
• ##STR23## wherein X is selected from the group consisting of alkyl groups, carbocyclic groups, and aryl groups.

A non-peptidyl compound represented by the formula:

• ##STR24## wherein A is 2,4-difluorophenyl or 4-nitrophenyl;
• B and C are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups;
• Y is a linker moiety selected from the group consisting of divalent alkyl groups, carbocyclic groups, and aryl groups;
• and
• D is selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, aryl groups, C(X)--Z--W, wherein X is O or S, Z is a single bond or NR;
• and R and W are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups.

A non-peptidyl compound represented by the formula:

• ##STR25## wherein A is 2-benzo[b]thienyl and;
• B and C are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups;
• Y is a linker moiety selected from the group consisting of divalent alkyl groups, carbocyclic groups, and aryl groups;
• and
• D is selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, aryl groups, C(X)--Z--W, wherein X is O or S, Z is a single bond or NR;
• and R and W are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups.

A non-peptidyl compound represented by the formula:

• ##STR26## wherein A is independently selected from the group consisting of alkyl groups, carbocyclic groups, and aryl groups;
• B and C are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups;
• Y is a linker moiety selected from the group consisting of divalent alkyl groups, carbocyclic groups, and aryl groups;
• and
• D is selected from the group consisting of 2-thienyl, 2-naphthyl, p-biphenyl, m-tolyl, 4-trifluoromethylphenyl, 2-furyl, 2-chlorophenyl, o-tolyl, 4-t-butylphenyl, 3-methoxyphenyl, 2,4-dichlorophenyl, 3-nitrophenyl, 4-bromophenyl, 1-naphthyl, 3-furyl, 3,4-methylenedioxyphenyl, 3-pyridyl, p-tolyl, 4-chlorophenyl, 4-nitrophenyl, m-fluorophenyl, p-fluorophenyl, p-cumenyl, benzyl, and cyclohexylmethyl.

A non-peptidyl compound represented by the formula:

• ##STR27## wherein A is independently selected from the group consisting of alkyl groups, carbocyclic groups, and aryl groups;
• B and C are each independently selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups;
• Y is a linker moiety selected from the group consisting of divalent alkyl groups, carbocyclic groups, and aryl groups;
• and
• D is --C(S)--NH--W wherein W is selected from the group consisting of hydrogen, alkyl groups, carbocyclic groups, and aryl groups.