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AssigneesBone Care International, Inc., The United States of America as represented by the Secretary of Agriculture
InventorsCharles W. Bishop, Ronald L. Horst, Glenville Jones, Nicholas J. Koszewski, Joyce C. Knutson, Robert M. Moriarty, Timothy A. Reinhardt, Raju Penmasta, Stephen Strugnell, Liang Guo, Sanjay K. Singhal, Lei Zhao
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1.alpha.,24(S)-Dihydroxy vitamin D.sub.2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1.alpha.,24(S)-dihydroxy vitamin D.sub.2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-Hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D.sub.2 which is converted in six steps to 1.alpha.,24(S)-dihydroxy vitamin D.sub.2. The syntheses also produced novel intermediates.
Substantially pure, crystalline 1.alpha.,24[(S)]-dihydroxyvitamin D.sub.2.
Dependencies are inferred from the claim text.