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US 6,143,903 AGranted
Process for the production of enantiomerically-pure azetidine-2-carboxylic acid
AssigneeAstra Aktiebolag
InventorsPhilipp Barth, Armin Pfenninger
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Abstract
The invention relates to a process for the production of enantiomerically-pure AzeOH which comprises selective crystallisation of a diastereomerically-pure AzeOH-tartrate salt from a homogeneous solution of AzeOH, optically-active tartaric acid, an organic acid and an aldehyde, followed by liberation of the free amino acid.
Claims18
A process for the production of enantiomerically-pure AzeOH which comprises:
- (a) selective crystallisation of a diastereomerically-pure AzeOH-tartrate salt from a homogeneous solution of AzeOH, optically-active tartaric acid, an organic acid and an aldehyde;
- followed by
- (b) liberation of the free amino acid.
A process for the conversion of one enantiomer of AzeOH to the other which comprises:
- (a) for conversion of D-AzeOH to L-AzeOH, selective crystallisation of a diastereomerically-pure L-AzeOH-D-tartrate salt from a homogeneous solution of D-AzeOH, D-tartaric acid, an organic acid and an aldehyde, followed by liberation of the free amino acid;
- or
- (b) for conversion of L-AzeOH to D-AzeOH, selective crystallisation of a diastereomerically-pure D-AzeOH-L-tartrate salt from a homogeneous solution of L-AzeOH, L-tartaric acid, an organic acid and an aldehyde, followed by liberation of the free amino acid.
Dependencies are inferred from the claim text.