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US 6,143,896 AGranted
Process for the alkylation of alkyl-or benzylcyanogen derivatives in the presence of trialkylamines or trialkylphosphines
AssigneeAventis Pharma Deutschland GmbH
InventorsGerhard Korb, Hans-Wolfram Flemming, Rudolf Lehnert
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Abstract
A process for the alkylation of compounds of the formula II ##STR1## where the reaction with the alkylating agent is carried out in the presence of a base and a trialkylamine and/or trialkylphosphine.
Claims31
A process for preparing a compound of formula I ##STR9## where R.sup.1 is 1. (C.sub.1 -C.sub.20)-alkyl,
- 2. (C.sub.1 -C.sub.20)-alkyl, which is mono-, di- or trisubstituted by
- 2.1. (C.sub.3 -C.sub.6)-cycloalkyl,
- 2.2. --OH,
- 2.3. (C.sub.1 -C.sub.6)-alkyl-C(O)--O--,
- 2.4. (C.sub.1 -C.sub.6)-alkyl-O--,
- 2.5. (C.sub.1 -C.sub.6)-alkyl-O--(C.sub.1 -C.sub.4)-alkyl-O--,
- 2.6. halogen,
- 2.7. --CF.sub.3,
- 2.8. --CN,
- 2.9. --NO.sub.2,
- 2.10. HO--C(O)--,
- 2.
9 more elements
Dependencies are inferred from the claim text.