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US 6,143,876 AGranted
Antibodies directed against binding-associated epitopes
AssigneeRamot University Authority for Applied Research and Industrial Development Ltd.
InventorJonathan M. Gershoni
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Abstract
Binding of two members of a binding couple reveals epitopes which are revealed only after binding and the monoclonal antibody secreted from the hybridoma cell line CG-10 directed against these epitopes bind to the bound couple at a significantly higher affinity than their binding affinity to either of the two members themselves when not bound to one another.
Claims10
An antigenic epitope which is a member of a group consisting of:
- (i) an epitope consisting of a sequence in a member of a binding couple, which becomes substantially more accessible to antibodies or resumes a new conformation after binding of the two members to one another,
- (ii) an epitope consisting of two or more sequences in a member of a binding couple which upon binding of the two members, become closely associated to form an antigenic epitope, and
- (iii) an epitope consisting of two or more sequences, at least one being in one member of a binding couple, and at least one other being in the other member of the binding couple and upon binding of the two members, said two or more amino acid sequences become closely associated with one another to form an antigenic epitope;
- said antigenic epitope being immunogenic.
1 more element
Dependencies are inferred from the claim text.