Antibodies to the neurotrophic factor NNT-1
AssigneeAmgen Inc.
InventorMing-shi Chang
Life of this patent
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Abstract
Disclosed are nucleic acids encoding novel neurotrophic factors, designated NNT-1. Also disclosed are amino acid sequences for NNT-1 polypeptides, methods for preparing NNT-1 polypeptides, and other related aspects. Such polypeptides are active in stimulating B-cell and/or T cell production, as well as reducing inflammatory responses.
Claims4
An isolated and purified antibody of fragment thereof which specifically binds to a polypeptide that has a biological activity of stimulating growth of motor or sympathetic neurons, said polypeptide selected from the group consisting of:
- (a) the polypeptide of SEQ ID NO:
- 2;
- (b) the polypeptide that is amino acids 1-198 of SEQ ID NO:
- 2;
- (c) the polypeptide that is at least 70% identical to the polypeptide of (a) or (b);
- and
- (d) a fragment of any of (a)-(c) which has said biological activity.
An isolated and purified antibody or fragment thereof which specifically binds to a polypeptide that has a biological activity of stimulating growth of motor or sympathetic neurons, said polypeptide selected from the group consisting of:
- (a') the polypeptide of SEQ ID NO:
- 5;
- (b') the polypeptide that is amino acids 1-198 of SEQ ID NO:
- 5;
- (c') the polypeptide that is at least 70% identical to the polypeptide of (a') or (b');
- and
- (d') a fragment of any of (a')-(c') which has said biological activity.
Dependencies are inferred from the claim text.