N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV
AssigneesUniroyal Chemical Company, Inc., Uniroyal Chemical Co./CIE.
InventorsWalter Gerhard Brouwer, Ewa Maria Osika
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Abstract
Compounds of the formula ##STR1## wherein A and X are independently oxygen or sulphur; R.sup.6 is H, halogen, alkyl, alkoxy, alkylthio, cyano, or nitro; Y is --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 S--, or --CH.sub.2 SO.sub.2 --; Q is a substituted or unsubstituted phenyl or aromatic heterocyclic group: useful for the inhibition of the replication of HIV-1, in vitro and in vivo.
Claims28
A compound of the formula ##STR13## wherein A and X are independently oxygen or sulfur;
- R.sup.6 is H, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, cyano, or nitro;
- Y is --CH.sub.2 O--, --OCH.sub.2 --, --CH.sub.2 S--, or --CH.sub.2 SO.sub.2 --;
- Q is:
- (A) a group of the structure ##STR14## wherein R.sup.1 to R.sup.5 are each independently:
- (i) hydrogen halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, C.sub.1 -C.sub.4 haloalkoxy, cyano, nitro, hydroxy, acetyloxy, benzoyloxy, amino, acetamido, phenyl, acetyloxymethyl, hydroxymethyl, trihalomethyl, carboxy, (C.sub.1 -C.sub.4 alkoxy)carbonyl, formyl, (C.sub.1 -C.sub.4 alkyl)carbonyl, benzoyl, or
- (ii) a group of the formula ##STR15## wherein R.sup.7 is H, linear or branched C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 haloalkyl, aminocarbonylmethyl, (C.sub.1 -C.sub.6 alkoxy)carbonylmethyl, or cyanomethyl, and R.sup.8 is hydrogen or methyl;
- or
- (B) a group of the formula ##STR16## wherein R.sup.9 is hydrogen, C.sub.1 -C.sub.4 alkyl, or C.sub.1 -C.sub.4 haloalkyl, and
- R.sup.10 is H, halogen, C.sub.1 -C.sub.4 alkyl or (C.sub.1 -C.sub.4 alkoxy)-carbonyl.
A compound of the formula ##STR19## wherein R.sup.1 to R.sup.5 are each independently hydrogen, fluoro, chloro, methyl, methoxy, trifluoromethyl, trifluoromethoxy, cyano, or nitro, wherein one or more of R.sup.2, R.sup.3, R.sup.4, and R.sup.5 are hydrogen.
A compound of the formula ##STR20##
Dependencies are inferred from the claim text.