Benzofuranone derivatives and a method for producing them
AssigneeSnow Brand Milk Products Co., Ltd.
InventorsMakoto Yoshihama, Masamichi Nakakoshi, Junji Nakamura, Shoji Nakayama
Life of this patent
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Abstract
The present invention provides new benzofuranone derivatives and a method for producing the derivatives useful for a therapeutic agent for preventing and/or treating hormone dependent diseases. The present invention is a new benzofuranone derivative represented by a particular general formula (I). ##STR1## In the production, a particular benzofuranone compound and a particular benzaldehyde are reacted.
Claims10
A new benzofuranone derivative represented by the following general formula (I):
- ##STR5## wherein R.sub.1 -R.sub.5 represent hydrogen, a hydroxy group, or a straight or branched alkyl, alkyloxy or aralkyloxy group having 1-7 carbon atoms, a halogen, an amino group or an alkylene dioxy group joined at R.sub.1 and R.sub.2, R.sub.2 and R.sub.3, R.sub.3 and R.sub.4, or R.sub.4 and R.sub.5, respectively, R.sub.6 represents a hydroxy group, or a straight or branched alkyloxy or an aralkyloxy group having 1-7 carbon atoms, or a caroboxylic acid ester having 1-7 carbon atoms with the proviso that when R.sub.2 and R.sub.6 are both hydroxy, then R.sub.1, R.sub.3, R.sub.4 and R.sub.5 are not hydrogen and further when R.sub.6 is a hydroxy group, and R.sub.1 R.sub.2, R.sub.4 and R.sub.5 are hydrogen, then R.sub.3 is not a methoxy group and still further when R.sub.2 and R.sub.6 are both hydroxy, and R.sub.1, R.sub.4 and R.sub.5 are hydrogen, then R.sub.3 is not hydroxy and yet still further when R.sub.4 and R.sub.6 are both hydroxy, and R.sub.1, R.sub.2 and R.sub.5 are hydrogen, then R.sub.3 is not hydroxy.
A pharmaceutical composition comprising:
- a compound of the formula (I):
- ##STR8## wherein R.sub.1 -R.sub.5 represent hydrogen, a hydroxy group, or a straight or branched alkyl, alkyloxy or aralkyloxy group having 1-7 carbon atoms, a halogen, an amino group or an alkylene dioxy group joined at R.sub.1 and R.sub.2, R.sub.2 and R.sub.3, R.sub.3 and R.sub.4, or R.sub.4 and R.sub.5, respectively, R.sub.6 represents a hydroxy group, or a straight or branched alkyloxy or an aralkyloxy group having 1-7 carbon atoms, or a caroboxylic acid ester having 1-7 carbon atoms with the proviso that when R.sub.2 and R6 are both hydroxy, then R.sub.1, R.sub.3, R.sub.4 and R.sub.5 are not hydrogen and further when R.sub.6 is a hydroxy group, and R.sub.1 R.sub.2, R.sub.4 and R.sub.5 are hydrogen, then R.sub.3 is not a methoxy group and still further when R.sub.2 and R.sub.6 are both hydroxy, and R.sub.1, R.sub.4 and R.sub.5 are hydrogen then R.sub.3 is not hydroxy and yet still further when R.sub.4 and R.sub.6 are both hydroxy, and R.sub.1, R.sub.2 and R.sub.5 are hydrogen, then R.sub.3 is not hydroxy;
- and a pharmaceutically acceptable carrier.
A method for treating an androgen or estrogen dependent disease in a mammal, said method comprising:
- administering a compound of the formula (I):
- ##STR9## wherein R.sub.1 -R.sub.5 represent hydrogen, a hydroxy group, or a straight or branched alkyl, alkyloxy or aralkyloxy group having 1-7 carbon atoms, a halogen, an amino group or an alkylene dioxy group joined at R.sub.1 and R.sub.2, R.sub.2 and R.sub.3, R.sub.3 and R.sub.4, or R.sub.4 and R.sub.5, respectively, R.sub.6 represents a hydroxy group, or a straight or branched alkyloxy or an aralkyloxy group having 1-7 carbon atoms, or a caroboxylic acid ester having 1-7 carbon atoms.
Dependencies are inferred from the claim text.