Imidazole n-benzyldioxol derivatives, method for preparing same, resulting intermediates, pharmaceutical compositions and use of said derivatives as endothelin antagonists
AssigneeHoechst Marion Roussel, Inc.
InventorsBertrand Heckmann, Simone Jouquey, Jean-Paul Vevert, Jidong Zhang
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Abstract
The invention relates to the new products of formula (I): ##STR1## in which: R.sub.1 represents alkyl, optionally substituted or cycloalkyl optionally interrupted by heteroatoms, R.sub.2 ; R.sub.3 both represent or carry an acid function or an acid isosteric function, and Y represents phenyl substituted in particular by a dioxol radical, these products being in all the isomeric forms and the salts, as medicaments.
Claims7
A compound selected from the group consisting of all possible racemic, enantiomeric and diastereoisomeric isomer forms of a compound of the formula ##STR38## wherein R.sub.1 is selected from the group consisting of a) alkyl of 1 to 6 carbon atoms unsubstituted or substituted with at least one hydroxy or alkoxy of 1 to 6 carbon atoms and b) saturated or unsaturated cycloalkyl of 3 to 7 ring members selected from the group consisting of carbon, oxygen, nitrogen and sulfur, R.sub.2 and R.sub.3 are individually an acid or acid isoteric group, Y is phenyl substituted with dioxol and optionally substituted with a member selected from the group consisting of halogen and alkyl and alkoxy of 1 to 4 carbon atoms and its salts with non-toxic, pharmaceutically acceptable acids or bases.
Dependencies are inferred from the claim text.