Compounds derived from 3-(benzofuran-5-yl)oxazolidin-2-one, preparation method therefor and therapeutical use thereof
AssigneeSynthelabo
InventorsSamir Jegham, Frederic Puech, Philippe Burnier, Danielle Berthon
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Abstract
Compounds derived from 3-(benzofuran-5-yl) oxazolidin-2-one, of general formula (I) ##STR1## in which: R.sub.1 represents a phenyl group, a phenylmethyl group, an alkyl group or a fluoroalkyl group, and R.sub.2 represents a hydrogen atom or a methyl group. Application in therapeutics.
Claims10
A compound of formula (I) in which:
- R.sub.1 represents a phenyl group, a phenylmethyl group, an alkyl group comprising 3 to 6 carbon atoms or a fluoroalkyl group comprising 1 to 6 carbon atoms, and R.sub.2 represents a hydrogen atom or a methyl group.
3-[2 -(3,3,3-Trifluoropropyl)benzofuran-5-yl]-5-methoxymethyloxazolidin-2-one and its enantiomers.
3-(2-Propylbenzofuran-5-yl)-5-methoxymethyloxazolidin-2-one and its enantiomers.
3-(2-Phenylbenzofuran-5-yl)-5-methoxymethyloxazolidin-2-one and its enantiomers.
A process for preparation of compounds of formula (I) ##STR9## in which:
- R.sub.1 represents a phenyl group, a phenylmethyl group, an alkyl group comprising 3 to 6 carbon atoms or a fluoroalkyl group comprising 1 to 6 carbon atoms, and R.sub.2 represents a hydrogen atom or a methyl group,
- which comprises reacting a compound of formula (IV) ##STR10## where R.sub.1 is as defined with respect to formula I, with 4-methoxymethyl-1,3-dioxolan-2-one to prepare the compounds of formula (I) where R.sub.2 is a methyl group.
Dependencies are inferred from the claim text.