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AssigneeD. Western Therapeutics Institiute
InventorsYasuo Koga, Yoshito Kihara, Minoru Okada, Takao Nishi, Yoshihiro Inoue, Yukio Kimura, Hiroyoshi Hidaka, Norio Fukuda
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A carbostyril derivative of the formula (1): ##STR1## wherein A is lower alkylene, R is H, halogen or lower alkoxy, R.sup.1 and R.sup.2 are each lower alkyl being optionally substituted by OH, lower alkoxy, phenyl-lower alkoxy or lower alkanoyloxy; cycloalkyl being optionally substituted by OH, hydroxy-lower alkoxy or lower alkanoyloxy; or amino being optionally substituted by lower alkyl or cycloalkyl, R.sup.3 is H, lower alkyl, lower alkenyl or hydroxy-lower alkyl, and the bond between 3- and 4-positions of the carbostyril nucleus is single or double, provided that when R and R.sup.3 are H, R.sup.1 and R.sup.2 should not be either unsubstituted lower alkyl or unsubstituted cycloalkyl, or a salt thereof, which shows antithrombotic activities, intima thickening inhibitory activity, the platelet mass dissociating activity and increasing activity of the blood flow in the brain and the peripheral vessel, and hence, is useful as medicines in the prophylaxis or treatment of various ischemic diseases.
A carbostyril compound of the formula ( 1):
A carbostyril compound of the formula (1):
A carbostyril compound of the formula (1):
6-{3-[3-(trans-2-Hydroxycycloh exyl)-3-cyclopropylureido]-propoxy}carbostyril.
(S,S)-(+)-6-{3-[3-(2-Hydroxycyclohexyl)-3-c yclopropylureido]-propoxy}carbostyril.
(R,R)-(-)-6-{3-[3-(2-Hydroxycycloh exyl)-3-cyclopropylureido]-propoxy}carbostyril.
6-{3-[3-(2-Hydroxycyclobutyl)-3-cyclopropylureido]propoxy}-carbostyril.
6-{3-[3-(N-Methyl-N-cyclohexylamino)ureido]propoxy}-carbostyril.
6-{3-[3-(N-Cyclopropyl-N-cyclohexylamino)ureido]-propoxy}carbostyril.
Dependencies are inferred from the claim text.