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US 6,143,759 AGranted
Tetrazoles
AssigneeByk Gulden Lomberg Chemische Fabrik GmbH
InventorDieter Flockerzi
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I) in which R.sup.4 is a phenyl radical substituted by R.sup.5, where R.sup.5 is a tetrazole-5-yl-radical optionally substituted by a radical R.sup.6, are novel efficacious PDE3/4 inhibitiors.
Claims12
A compound of formula I ##STR5## in which R1 is 1-4C-alkyl,
- R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine,
- R3 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine, or in which
- R2 and R3 together are a 1-2C-alkylenedioxy group,
- R4 is a phenyl radical substituted by R5, where
- R5 is a tetrazol-5-yl radical substituted by a radical R6, where
- R6 is hydrogen, 1-10C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or Ar-1-4C-alkyl, where
- Ar is a phenyl radical which is unsubstituted or substituted by R7 and/or R8, and
- R7 and R8 independently of one another are 1-4C-alkyl or 1-4C-alkoxy, or a salt thereof.
5 more elements
Dependencies are inferred from the claim text.