Pharmaceutical composition for the treatment of malignant neoplasms and immunosuppressive deficiencies and its method of production

#The present invention refers to a pharmaceutical composition for the treatment of malignant neoplasms and immunosuppressive deficiencies, by re-establishing the biochemical balance within the cells, mainly those cells undergoing a disordered reproduction, and to a method for producing said pharmaceutical composition.

#Nowadays, the existence of several types of cancer control by means of conventional treatments has conducted, after studies based on cellular biochemistry, to the provision of a pharmaceutical composition formed by an essential aminoacid of the benzoic genesis and by a genetic derivative of a pyrimidinic nitrogenized base. The experiment has clinically proved its efficiency on the neoplastic cells, avoiding their disordered reproduction.

#Thus, it is a first objective of the present invention to use the efficiency of the active ingredients of an essential aminoacid of the benzoic genesis with a pyrimidinic nitrogenized base in a biologically acceptable pharmaceutical formula in the following compositions: DL-kinurenine, [2-amine-3-(2-aminebenzene)propionic acid] and tymine, [2,1 dihydroxy-5-methyl-pyrimidine;5-methyluracil].

#The knowledge of the chromosomal structures, DNA and RNA components, as well as the related biochemical reactions has permitted the detection of a defect in the ribonucleasidase of the purines. By using the essential aminoacid resulting from the transformation of anthranil, 2-benzoic aminoacid, into tryptophan and finally into DL-kinurenine, which is the third degree of the benzoic genesis of these aminoacids, associated with a pyrimidinic nitrogenized base, the tymine [2,4 dihydroxy-5-methylpyrimidine;5-methyluracil], it has been detected a cellular biochemical reaction taking place in the nucleosides and nucleotides of the neoplastic cells, by the enzymatic action of carboxylase. This biochemical reaction of the active ingredients of the product has the purpose of eliminating the energy produced by oxygen release and of neutralizing the nitrogen of the formylic radicals produced in the disordered cellular mitosis of the neoplastic cells. In this biochemical reaction of the cell, 5-methyluracil re-establishes the cellular genesis and DL-kinurenine eliminates the nitrogenized methylic and formylic radicals which appear during the cellular mitosis. 5-methyluracil re-establishes the bridge with the deoxyribonucleoside, with the atypical chromosomes being eliminated, since they do not obey the benzoic genesis of the cell (Lawitscka, Reseach Informative Data, 1960-1980); (Jones, 1980,49:253-279); Fraile, 1980, 2223-2228; Valeriote and Santelli, 1984, 107-132 and Jones, 1979,98:1-8).

#The nucleotides and nucleosides of the normal cells take the cell to a mitosis, in which the chromosomes are multiplied in pairs and not as it occurs in the neoplastic cell, in which the multiplication takes place in groups of four.

#The four purinic nitrogenized bases of DNA and RNA (Adenine and Guanine, A and G) and pyrimidinic bases of DNA (Citosine and Tymine, C and T) and of RNA (Citosine and Uracil, C and U), which are components of the nucleic acids, form together with glucose (pentose) the first link for the fusocellular mitosis, by action of ribonucleosidase, which effects the cellular mitotic genesis. A failure in this formation of the purines makes the cell become cancerous. A purine may be replaced by a ribonucleoside, but not in the cellular mitosis. In the mitosis it is irreplaceable. The oxyribonuclease and deoxyribonuclease enzymes are present in the mitotic cellular genesis, transformed by carboxylase. Deoxyribonuclease is the carrier of the cellular genesis and allows the communication among the chromosomes by means of 5-methyluracil, which eliminates the free oxygen by action of kinurenine over the formylic radicals, transforming in oxy-kinurenine formyl, neutralizing the energy of the cancerous cell. Once re-established the bridge with the deoxyribonucleoside by the transformation of uracil into 5-methyluracil- in the presence of tryptophan, transformed into oxykinurenine formyl, the formylic and methylic nitrogenized radicals are eliminated, allowing the cell to return to a normal mitosis (Lawitscka, Informative Data, 1960).