Sulfamide-metalloprotease inhibitors

A compound selected from the group of compounds represented by formula (I):

• ##STR41## wherein:
• R.sup.1 and R.sup.2 are independently selected from hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclo, heterocycloalkyl, heteroalkyl, or -(alkylene)-C(O)-X where X is alkyl, haloalkyl, alkoxy, haloalkyloxy, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, aryloxy, heteroaryloxy, hydroxy, aralkyloxy, heteroaralkyloxy, or heteroaryl;
• or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form a carbocycle or a heterocycle;
• R.sup.3 is hydrogen, alkyl, alkenyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaryl, heteroaralkyl, heteroaralkenyl, heterocycloalkyl, heteroalkyl, (diphenylmethyl)alkyl, or -(alkylene)-C(O)-X where X is alkyl, haloalkyl, alkoxy, haloalkyloxy, amino, monosubstituted amino, disubstituted amino, aryl, aralkyl, aryloxy, heteroaryloxy, hydroxy, aralkyloxy, heteroaralkyloxy, or heteroaryl;
• or R.sup.3 together with either R.sup.1 or R.sup.2 and the atoms to which they are attached forms a heterocycloamino group;
• R.sup.10 is --NR.sup.11 OR.sup.12 wherein:
• R.sup.11 and R.sup.12 are independently selected from hydrogen, alkyl, or aralkyl;
• R.sup.20 and R.sup.21 are independently selected from hydrogen, alkyl, heteroalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, aralkenyl, heteroaralkyl, or heteroaralkenyl;
• or R.sup.20 and R.sup.21 together with the nitrogen atom to which they are attached form a heterocycloamino group or an optionally substituted tetrahydropyridine or hexahydroazepine ring;
• or either of R.sup.20 or R.sup.21 together with R.sup.3 forms an alkylene group;
• and
• their pharmaceutically acceptable salts, prodrugs, individual isomers, and mixtures of isomers, provided that R.sup.20 and R.sup.21 together with the nitrogen atom to which they are attached do not form a morpholino ring either:
• (i) when R.sup.1 and R.sup.3 are hydrogen and R.sup.2 is aralkyl;
• or
• (ii) when R.sup.1 and R.sup.3 together with the atoms to which they are attached form a tetrahydroisoquinoline ring and R.sup.2 is hydrogen.