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US 6,143,737 AGranted
Progesterone analogs to reverse multidrug resistance
AssigneeGeorgetown University
InventorsRobert Clarke, Abdel H. Talebian, Alem Ghiorghis, Fabio Leonessa, Charles Hammer
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Abstract
The present invention is directed to compounds of formula I ##STR1## wherein the substituents are as defined in the specification. Also disclosed are compositions and method of use of the compounds.
Claims10
A compound of Formula I:
- ##STR3## or a pharmaceutically acceptable salt thereof;
- wherein
- X is a bond, or is one of --C(O)--, --C(O)NH-- or --C(O)NHSO.sub.2 --;
- R.sup.1 is one of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, dihaloalkyl, optionally substituted aralkynyl, alkoxyalkyl, aminoalkyl, cyanoalkyl, thiocyanoalkyl, azidoalkyl, optionally substituted arylalkyl, optionally substituted arylalkenyl or optionally substituted aryl;
- and
- R.sup.2 is one of hydrogen, halogen, hydroxy, alkoxy, alkoxycarbonyl, alkoxymethyl, acyloxymethyl, hydroxymethyl or --OR.sup.3, where R.sup.3 is one of alkanoyl, a hemisuccinoyl group or benzoyl.
3 more elements
Dependencies are inferred from the claim text.