Sesquiterpene derivatives

A compound of the formula:

• ##STR23## wherein R.sup.1 is hydrogen or halogen;
• and R.sup.2 is hydrogen, halogen, azido, an optionally substituted lower alkyl, an optionally substituted lower alkylcarbonyl, an optionally substituted arylcarbonyl, an optionally substituted heteroarylcarbonyl, --OR.sup.7 (wherein R.sup.7 is hydrogen, an optionally substituted lower alkyl, an optionally substituted lower alkylcarbonyl, an optionally substituted arylcarbonyl, an optionally substituted heteroarylcarbonyl, an optionally substituted lower alkylsulfonyl, an optionally substituted arylsulfonyl, an optionally substituted heteroarylsulfonyl, --SO.sub.3 H, an optionally substituted aryl, an optionally substituted aralkyl, an optionally substituted carbamoyl, or --PO.sub.3 H.sub.2), S(O).sub.n R.sup.13 (wherein R.sup.13 is hydrogen, an optionally substituted lower alkyl, or an optionally substituted aryl, and n is 0, 1, or 2), or --NHR.sup.8 (wherein R.sup.8 is hydrogen, an optionally substituted lower alkyl, an optionally substituted lower alkylcarbonyl, an optionally substituted lower alkylsulfonyl, an optionally substituted arylcarbonyl, an optionally substituted aralkyloxycarbonyl, an optionally substituted arylsulfonyl, an optionally substituted heteroarylsulfonyl, or an optionally substituted carbamoyl);
• or R.sup.1 and R.sup.2 taken together may form oxo or .dbd.NR.sup.9 (wherein R.sup.9 is hydroxy, a lower alkoxy, an optionally substituted aralkyl, an optionally substituted arylsulfonylamino, or --NHCONH.sub.2);
• R.sup.3 is hydrogen or halogen;
• and R.sup.4 is hydrogen, halogen, --OR.sup.10 (wherein R.sup.10 is hydrogen, an optionally substituted lower alkyl, an optionally substituted lower alkylcarbonyl, an optionally substituted arylcarbonyl, an optionally substituted heteroarylcarbonyl, an optionally substituted lower alkylsulfonyl, an optionally substituted arylsulfonyl, an optionally substituted heteroarylsulfonyl, --SO.sub.3 H, or --PO.sub.3 H.sub.2), SR.sup.14 (wherein R.sup.14 is hydrogen, an optionally substituted lower alkyl, or an optionally substituted aryl), or --NHR.sup.11 (wherein R.sup.11 is hydrogen, an optionally substituted lower alkyl, an optionally substituted lower alkylcarbonyl, an optionally substituted lower alkylsulfonyl, an optionally substituted arylsulfonyl, an optionally substituted heteroarylsulfonyl, or an optionally substituted carbamoyl);
• or R.sup.3 and R.sup.4 taken together may form oxo or .dbd.NR.sup.12 (wherein R.sup.12 is hydroxy, cyano, amino, an optionally substituted lower alkoxy, an optionally substituted aralkyl, an optionally substituted arylsulfonylamino, an optionally substituted aliphatic heterocyclic group, or --NHCONH.sub.2);
• or R.sup.2 and R.sup.4 taken together may form an unsaturated bond or --O--;
• A is .dbd.NR.sup.5 (wherein R.sup.5 is hydrogen, lower alkyl, lower alkylcarbonyl, or lower alkylsulfonyl;
• or R.sup.5 and Z.sup.1 taken together may form an unsaturated bond);
• R.sup.6 is hydrogen, cyano, nitro, amino, halogen, an optionally substituted carboxy, or an optionally substituted carbamoyl;
• X is hydrogen, cyano, nitro, amino, halogen, hydroxy, lower alkoxy, an optionally substituted carboxy, an optionally substituted carbamoyl;
• Y.sup.1 and Y.sup.2 are both hydrogens, or taken together may form oxo;
• Z.sup.1 and Z.sup.2 are both hydrogens, or taken together may form oxo, or Z.sup.1 is hydrogen and Z.sup.2 is hydroxy, an optionally substituted lower alkyl, or an optionally substituted lower alkoxy, or an optionally substituted aryl),
• the pharmaceutically acceptable salt, or the hydrate thereof.