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US 6,143,529 AGranted
Methods for improving sensitivity and specificity of screening assays
AssigneeExact Laboratories, Inc.
InventorsStanley N. Lapidus, Anthony P. Shuber
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Abstract
Methods of the invention comprise assays for markers indicative of cancer or precancer. Assays of the invention are performed on samples obtained from a patient by non-invasive or minimally-invasive methods. The invention provides nucleic acid indicia of cancer or precancer with high sensitivities and high specificities for detection.
Claims33
A method of screening a human patient for cancer or precancer, the method comprising the steps of:
- (a) determining, in a patient sample of a bodily excretion or a bodily fluid, the amount of DNA greater than about 200 bp in length;
- and
- (b) comparing said amount to the amount of DNA greater than about 200 bp in length expected to be present in a sample obtained from a healthy patient,
- wherein a statistically significant larger amount of nucleic acids greater than about 200 bp in length in said patient sample indicates a positive screen.
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Dependencies are inferred from the claim text.