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US 6,143,523 AGranted
Human growth hormone variants
AssigneeGenentech, Inc.
InventorsBrian C. Cunningham, Henry Lowman, James A. Wells
Life of this patent
Estimating the term…
Abstract
Human growth hormone variants and their nucleic acids are disclosed wherein the amino acid residues at positions 10, 14, 18, 21, 167, 171, 174, 176 and 179 have been replaced with other amino acids. Also claimed are vectors and host cells comprising these human growth hormone variants as well as processes for their preparation.
Claims6
A nucleic acid encoding a human growth hormone variant comprising a set of amino acid substitutions selected from the group consisting of:
- R167N, D171S, E174S, F176Y, I179T;
- R167E, D171S, E174S, F176Y;
- F10A, M14W, H18D, H21N;
- F10A, M14W, H18D, H21N, R167N, D171S, E174S, F176Y, I179T;
- F10A, M14W, H18D, H21N, R167N, D171A, E174S, F176Y, I179T;
- F10H, M14G, H18N, H21N;
- F10A, M14W, H18D, H21N, R167N, D171A, T175T, I179T;
- and
- F10I, M14Q, H18E, R167N, D171S, I179T.
6 more elements
A human growth hormone variant comprising a set of amino acid substitutions selected from the group consisting of:
- R167N, D171S, E174S, F176Y, I179T;
- R167E, D171S, E174S, F176Y;
- F10A, M14W, H18D, H21N;
- F10A, M14W, H18D, H21N, R167N, D171S, E174S, F176Y, I179T;
- F10A, M14W, H18D, H21N, R167N, D171A, E174S, F176Y, I179T;
- F10H, M14G, H18N, H21N;
- F10A, M14W, H18D, H21N, R167N, D171A T175T, I179T;
- and
- F10I M14Q, H18E, R167N, D171S, I179T.
6 more elements
Dependencies are inferred from the claim text.