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US 6,143,516 AGranted
Identification of novel antimicrobial agents using membrane potential indicator dyes
AssigneeXoma Technology Ltd.
InventorsRoger G. Little, II, Susan Abrahamson, Peter Wong
Life of this patent
Estimating the term…
Abstract
Novel screening methods for identifying antimicrobial agents involving use of membrane potential indicator dyes are provided.
Claims11
A method of identifying an antifungal compound comprising the steps of:
- (a) contacting fungal cells with a test compound and with a membrane potential indicator dye, and
- (b) detecting an increasing accumulation of said dye and retention of dye despite reduction of fungal cell viability.
A method of identifying an antibacterial compound comprising the steps of:
- (a) contacting bacterial cells with a test compound and with a membrane potential indicator dye, and
- (b) detecting an increasing accumulation of said dye and retention of dye despite reduction of bacterial cell viability.
A method of identifying an antimicrobial compound comprising the steps of:
- (a) contacting microbial cells with a test compound and with a membrane potential indicator dye, and
- (b) detecting an increasing accumulation of said dye and retention of dye despite reduction of microbial cell viability.
Dependencies are inferred from the claim text.