Diagnostic method for detection of periodontitis or peri-implantitis
AssigneeResearch Foundation of State of N.Y.
InventorsLorne M. Golub, Timo Sorsa, Olli Teronen, Sari Hannele Tikanoja
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Abstract
The invention relates to methods and test kits for diagnosis of periodontal disease activity in mammals, especially in human. The methods of the invention provide for rapid chair-side diagnosis of periodontitis, peri-implantitis and HIV (+)-infection/AIDS-disease related periodontal diseases. Especially, the methods of the invention provide for rapid chair-side diagnosis of the loss of bone density associated with periodontal diseases.
Claims8
A method for monitoring the course and treatment of periodontal disease or peri-implantitis wherein the detection comprises the steps of:
- (a) collecting a gingival crevicular fluid, peri-implant sucular fluid, saliva or mouthrinse sample;
- (b) contacting said sample with at least one molecule which recognizes mammalian matrix metalloproteinase-13 in said sample;
- and
- (c) detecting the presence of said mammalian matrix metalloproteinase-13, wherein an increased level of MMP-13 indicates periodontal disease or peri-implantitis.
Dependencies are inferred from the claim text.