Laminin chains: diagnostic and therapeutic use
OwnerKarl Tryggvason, Pekka Kallunki +1inventors
InventorsKarl Tryggvason, Pekka Kallunki, Charles Pyke
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Abstract
The instant invention provides for the identification, diagnosis, monitoring, and treatment of invasive cells using the laminin 5 gamma-2 chain protein or nucleic acid sequence, or antibodies thereto.
Claims4
A method for determining the presence of invasive cells in a tumor tissue by detecting the presence of laminin 5 gamma-2 chain protein in said tumor tissue, comprising contacting said tumor tissue with an antibody which specifically binds to the gamma-2 chain of said laminin 5 protein to form an immunocomplex, and detecting formation of any immunocomplex, wherein said formation of said immunocomplex correlates with the presence of said invasive cells in said tumor tissue.
A method for determining the presence of invasive cells in a colon carcinoma by detecting the presence of laminin 5 gamma-2 chain protein in said colon carcinoma, comprising contacting said colon carcinoma with an antibody which specifically binds to the gamma-2 chain of said laminin 5 protein to form an immunocomplex, and detecting formation of any immunocomplex, wherein said formation of said immunocomplex correlates with the presence of said invasive cells in said colon carcinoma.
A method for determining the presence of invasive cells in a squamous cell carcinoma by detecting the presence of laminin 5 gamma-2 chain protein in said squamous cell carcinoma, comprising contacting said squamous cell carcinoma with an antibody which specifically binds to the gamma-2 chain of said laminin 5 protein to form an immunocomplex, and detecting formation of any immunocomplex, wherein said formation of said immunocomplex correlates with the presence of said invasive cells in said squamous cell carcinoma.
Dependencies are inferred from the claim text.