Therapeutic compositions and methods and diagnostic assays for type II diabetes involving HNF-1
AssigneeMillennium Pharmaceuticals, Inc.
InventorM. Alexandra Glucksmann
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Abstract
Method and compositions for treating type II diabetes; and type II diabetes diagnostics are disclosed
Claims10
A method for determining whether a human subject has or is at risk for developing type II diabetes comprising determining the identity of the amino acid at position 131 of the HNF-1 protein, wherein the presence of an amino acid other than arginine identifies a subject that has or is at risk of developing type II diabetes.
A method for determining whether a human subject has or is at risk for developing type II diabetes comprising determining whether the protein encoded by HNF-1 gene is truncated at the residue encoded by the codon beginning at position 968.
Dependencies are inferred from the claim text.