Delayed release coated tablet of bupropion hydrochloride
AssigneePharma Pass LLC
InventorPawan Seth
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Abstract
The invention provides a delayed release coated tablet, free of stabilizer and free of pore-forming agent comprising: (i) a core consisting essentially of bupropion hydrochloride, a binder and a lubricant; and (ii) a first coating consisting essentially of a water-insoluble, water-permeable film-forming polymer, a plasticizer and a water-soluble polymer; and (iii) a second coating consisting essentially of a methacrylic polymer and a plasticizer therefor.
Claims19
A delayed release coated tablet comprising:
- (i) a core comprising bupropion hydrochloride and conventional excipients, free of stabilizer;
- and
- (ii) a first coating consisting essentially of a water-insoluble, water-permeable film-forming polymer, a plasticizer and a water-soluble polymer;
- and
- (iii) a second coating consisting essentially of a methacrylic polymer and a plasticizer therefor;
- exhibiting a dissolution profile such that after 2 hours, from 0 up to 30% of the bupropion hydrochloride is released, after 4 hours, from 3 to 22% of the bupropion hydrochloride is released, after 6 hours, from 15 to 38% of the bupropion hydrochloride is released, after 8 hours, more than 40% of the bupropion hydrochloride is released.
A delayed release coated tablet comprising:
- (i) a core consisting essentially of bupropion hydrochloride, polyvinylalcohol and glyceryl behenate;
- and
- (ii) a first coating consisting essentially of ethylcellulose, polyvinylpyrrolidone and polyethyleneglycol;
- and
- (iii) a second coating consisting essentially of methacrylic acid co-polymer, triethyl citrate, polyethyleneglycol and optionally silicon dioxide;
- exhibiting a dissolution profile such that after 2 hours, from 0 up to 30% of the bupropion hydrochloride is released, after 4 hours, from 3 to 22% of the bupropion hydrochloride is released, after 6 hours, from 15 to 38% of the bupropion hydrochloride is released, after 8 hours, more than 40% of the bupropion hydrochloride is released.
A bupropion hydrochloride delayed release coated tablet free of stabilizer and free of pore-forming agent, exhibiting a dissolution profile such that after 2 hours, from 0 up to 30% of the bupropion hydrochloride is released, after 4 hours, from 3 to 22% of the bupropion hydrochloride is released, after 6 hours, from 15 to 38% of the bupropion hydrochloride is released, after 8 hours, more than 40% of the bupropion hydrochloride is released.
Dependencies are inferred from the claim text.