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US 6,143,321 AGranted
Liposomes containing active agents
AssigneeDuke University
InventorsDavid Needham, Ranjit S. Sarpal
Life of this patent
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Abstract
Liposomes formulations are designed to maximize the amount of poorly water-soluble active agent that can be carried by the liposome. Liposomes containing active agent in the lipid bilayer of the liposome, and/or entrapped within the liposome interior space in a micellar preparation are described. Methods of making such liposomes are presented.
Claims14
A liposome containing an active agent, said liposome comprising:
- (a) a lipid unilaminar bilayer comprising phospholipid, lipid surfactant with a Critical Micelle Concentration (CMC) of about 1 millimolar or less, and from 3 mole percent to 60 mole percent of cholesterol;
- and
- (b) a micellar preparation comprising active agent aggregated with the lipid surfactant to form micelles, said micelles entrapped within the interior space of the liposome;
- and said cholesterol is contained in the lipid bilayer in an amount sufficient to increase the stability of the micelle-containing liposome compared to that which would occur in the absence of cholesterol.
1 more element
A liposome containing paclitaxel, said liposome comprising:
- (a) a lipid unilaminar bilayer comprising phospholipid, lysophosphatidylcholine, and cholesterol in a mole ratio of about 8:4:3, and
- (b) a micellar preparation comprising paclitaxel aggregated with lysophosphatidylcholine micelles, said micelles entrapped within the interior space of the liposome.
Dependencies are inferred from the claim text.