Transdermal therapeutic system containing estradiol
AssigneesLTS Lohmann Therapie-Systeme AG, Merck Patent GmbH
InventorsReinhold Meconi, Frank Seibertz, Michael Horstmann, Rainer Lichtenberger
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Abstract
An active-substance-containing transdermal therapeutic system for the controlled release of estradiol or its pharmaceutically acceptable derivatives alone or combined with gestagens consisting of a backing layer, an active-substance-containing reservoir which is bonded thereto and produced by using pressure sensitive adhesives, and a removable protective layer is characterized by the fact that the pressure sensitive adhesive comprises esters of colophony.
Claims24
A transdermal therapeutic system for the controlled release of estradiol or its pharmaceutically acceptable derivatives, alone or in combination with a gestagen, said transdermal therapeutic system comprising:
- a backing layer,
- an active substance containing reservoir which is connected to said backing layer, said reservoir comprises one or more layers of a pressure sensitive adhesive, wherein the pressure sensitive adhesive contains esters of colophony or esters of hydrogenated colophony in an amount of 55-92%-wt. and an additional organic polymer which is selected from:
- a) a cellulose ether when the active substance is estradiol or its pharmaceutically acceptable derivative alone, or
- b) a synthetic rubber polymer when the active substance is a combination of estradiol or its pharmaceutically acceptable derivative with a gestagen.
Dependencies are inferred from the claim text.