Back to results
US 6,143,293 AGranted
Assembled scaffolds for three dimensional cell culturing and tissue generation
AssigneesCarnegie Mellon, University of Pittsburgh
InventorsLee E. Weiss, Jay Wynn Calvert
Life of this patent
Estimating the term…
Abstract
A three-dimensional scaffold for tissue generation. Mechanical fasteners allow layered and volumetric scaffold sections, which may be pre-seeded with cells and/or growth factors, to be assembled into a heterogeneous generated tissue for implantation.
Claims19
A three dimensional multilayer scaffold for supporting cell growth comprising:
- a first layer for supporting cell growth;
- and
- a second layer for supporting cell growth, said first and second layers being mechanically fastened together.
A method of forming a three dimensional multilayer scaffold comprising:
- seeding a first prefabricated element with a component selected from the group consisting of living cells, bone marrow cells, osteoblasts, mesenchymal stem cells, satellite cells, fibroblasts, and growth factors;
- seeding a second prefabricated element with a component selected from the group consisting of living cells, bone marrow cells, osteoblasts, mesenchymal stem cells, satellite cells, fibroblasts, and growth factors;
- and
- connecting said first and second prefabricated elements together in a manner that ensures viability of said cellular components.
1 more element
A method of treating a patient comprising:
- constructing a three dimensional scaffold to support cell growth, said three dimensional scaffold including a first layer for supporting cell growth, and a second layer for supporting cell growth, said first and second layers being mechanically connected to each other;
- and
- implanting said three dimensional scaffold in the patient.
Dependencies are inferred from the claim text.