Metered dose inhaler for salmeterol
AssigneesGlaxo Wellcome Inc., Glaxo Group Limited
InventorsIan C. Ashurst, Craig S. Herman, Li Li, Michael T. Riebe
Life of this patent
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Abstract
A metered dose inhaler having part or all of its internal metallic surfaces coated with one or more fluorocarbon polymers, in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents and one or more excipients.
Claims45
A metered dose inhaler containing therein an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof, and a fluorocarbon propellant comprising 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoro-n-propane or a mixture thereof, wherein said metered dose inhaler has part or all of its internal surfaces coated with a polymer blend comprising (i) one or more fluorocarbon polymers comprising monomeric units made from one or more monomers selected from the group consisting of tetrafluoroethylene, hexafluoropropylene, perfluoroalkoxyalkylene, and vinylidene fluoride in combination with (ii) one or more non-fluorocarbon polymers selected from the group consisting of a polyamide, a polyimide, a polyamideimide, a polyethersulphone, a polyphenylene sulfide and an amine-formaldehyde thermosetting resin.
An inhaler according to 1, wherein said drug formulation consists essentially of salmeterol or a physiologically acceptable salt thereof, optionally in combination with one or more other pharmacologically active agents, and a fluorocarbon propellant.
A metered dose inhaler containing therein an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof in the form of particles having a particle size less than 100 microns in an amount of 0.005 to 10% by weight relative to the total weight of the formulation and a fluorocarbon propellant which is 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoro-n-propane or a mixture thereof, wherein said metered dose inhaler has part or all of its internal surfaces coated with a blend of (i) one or more fluorinated polymers which is made of multiples of one or more monomeric units selected from the group consisting of tetrafluoroethylene, perfluorinated ethylene propylene, perfluoropropyl vinyl ether, ethylene tetrafluoroethylene, vinylidene fluoride and chlorinated ethylene tetrafluoroethylene and (ii) a non-fluorinated polymer selected from the group consisting of a polyamide, a polyimide, a polyamideimide, a polyethersulphone, a polyphenylene sulfide and an amine-formaldehyde thermosetting resin.
A metered dose inhaler containing therein an inhalation drug formulation comprising 0.005 to 10% by weight of salmeterol or a physiologically acceptable salt thereof relative to the total weight of said drug formulation, said salmeterol or a physiologically acceptable salt thereof having a particle size less than 100 microns and a fluorocarbon propellant which is 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoro-n-propane or a mixture thereof, comprising:
- a metal can having a mouth, said can having on its internal surface a coating having a thickness of 1 .mu.m to 1 mm comprising a blend of one or more fluorinated polymers which is made of multiples of one or more monomeric units selected from the group consisting of tetrafluoroethylene, perfluorinated ethylene propylene, perfluoropropyl vinyl ether, ethylene tetrafluoroethylene, vinylidene fluoride and chlorinated ethylene tetrafluoroethylene and a non-fluorinated polymer selected from the group consisting of a polyamide, a polyamideimide, a polyethersulphone, a polyphenylene sulfide and an amine-formaldehyde thermosetting resin;
- a cap covering said mouth of said can;
- and
- a drug metering value situated in said cap.
Dependencies are inferred from the claim text.