Type S.sub.3 N.sub.2 chelators for radioactive isotopes, their metal complexes and their diagnostic and therapeutical use

A conjugate of a compound, the conjugate containing a substance that accumulates selectively in diseased tissues, with a covalent bond existing between the compound and the substance, said bond being amidic if the substance contains a carboxy or an amino group, ester-like if the substance contains a hydroxy group, and imidic if the substance contains aldehyde groups, the compound having the general formula (II)

• B--CO--CR.sup.1 R.sup.2 --A--CR.sup.3 R.sup.4 CO--D (II)
• wherein
• A is selected from the group consisting of an O chalcogen atom, an S chalcogen atom, and an Se chalcogen atom,
• R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are the same or different and are selected from the group consisting of a hydrogen atom, and a branched or unbranched C.sub.1 -C.sub.6 alkyl group,
• B and D are the same or different and represent a residue
• --NH--(CR.sup.5 R.sup.5)--(CR.sup.7 R.sup.8).sub.n=1,2 --S--R.sup.9,
• wherein
• R.sup.5 and R.sup.6 are the same or different and are selected from the group consisting of a hydrogen atom and an unbranched, branched, cyclic, or polycyclic C.sub.1 -C.sub.60 alkyl, alkenyl, polyalkenyt, alkynyl, polyalkynyl, aryl, alkylaryl, or arylalkyl group which optionally carry one or more additional hydroxy, carboxy, aminocarbonyl, alkoxycarbonyl, amino, aldehyde, oxo, oxy, or alkoxy groups containing up to 20 carbon atoms, optionally interrupted or replaced, by one or several heteroatoms selected from the group consisting of O, N, S, P, As, and Se,
• R.sup.7 and R.sup.8 are the same or different and are selected from the group consisting of a hydrogen atom, and a branched or unbranched C.sub.1 -C.sub.6 alkyl group,
• R.sup.9 is selected from the group consisting of a hydrogen atom, a branched or unbranched C.sub.1 -C.sub.6 alkyl group, and a sulfur protecting group,
• with R.sup.9 and R.sup.5, together with the groups that connect them, optionally forming a 4- to 8-membered ring which optionally carry one or more additional hydroxy, oxo, oxy, or alkoxy groups containing up to 6 carbon atoms,
• and a complex thereof with radioisotopes of Tc or Re.

A compound of the general formula (II)

• B--CO--CR.sup.1 R.sup.2 --A--CR.sup.3 R.sup.4 --CO--D (II)
• wherein
• A is selected from the group consisting of an O chalcogen atom, an S chalcogen atom, and an Se chalcogen atom,
• R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are the same or different and are selected from the group consisting of a hydrogen atom, and a branched or unbranched C.sub.1 -C.sub.6 alkyl group,
• B and D are the same or different and represent a residue
• --NH--(CR.sup.6 R.sup.6)--(CR.sup.7 R.sup.8).sub.n=1,2 --S--R.sup.9,
• wherein
• R.sup.5 and R.sup.6 are the same or different and are selected from the group consisting of a hydrogen atom and an unbranched, branched, cyclic, or polycyclic C.sub.1 -C.sub.60 alkyl, alkenyt, polyalkenyl, alkynyl, polyalkynyl, aryl, alkylaryt, or arylalkyl residue which optionally carry one or more additional hydroxy, carboxy, aminocarbonyl, alkoxycarbonyl, amino, aldehyde, oxo, oxy, or alkoxy groups containing up to 20 carbon atoms, optionally interrupted or replaced by one or several heteroatoms selected from the group consisting of O, N, S, P, As, and Se,
• R.sup.7 and R.sup.8 are the same or different and are selected from the group consisting of a hydrogen atom, and a branched or unbranched C.sub.1 -C.sub.6 alkyl group,
• R.sup.9 is selected from the group consisting of a hydrogen atom, a branched or unbranched C.sub.1 -C.sub.6 alkyl group, and a sulfur protecting group, with R.sup.9 and R.sup.5, together with the groups that connect them, optionally forming a 4- to 8-membered ring which optionally carry one or more additional hydroxy, oxo, oxy, or alkoxy groups containing up to 6 carbon atoms,
• and a complex thereof with radioisotopes of Tc or Re.