Process for the preparation of 4-(des-dimethylamino)-tetracyclines
AssigneeHovione Inter Ltd.
InventorsWilliam Heggie, Jose Galindro, Pedro Santos, Luis Carvalho
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Abstract
The present invention refers to a process for the preparation of 4-(des-dimethylamino)-tetracyclines, which compounds have a therapeutical application. The starting tetracyclines are treated with a methylating agent and the resulting trimethylammonium salts are reduced by electrolysis in an aqueous solution at acidic pH, in the presence of an adequate electrolyte. A direct electrical current with a potential of 0.5-1.5 volts is applied between two convenient electrodes until the reaction is complete. The 4-(des-dimethylamino)-tetracyclines are isolated by extraction with an organic solvent.
Claims14
A process for the preparation of a 4-(des-dimethylamino)-tetracyclines by reduction of an ammonium salt of a tetracycline, characterised in that the reduction is effected electrochemically.
Dependencies are inferred from the claim text.