Compositions and methods for coating medical devices

An in vivo medical treatment device coated with a polymeric matrix, said polymeric matrix comprising a biocompatible biodegradable polymer and a pharmaceutically effective amount of a pharmaceutical agent, wherein the polymeric matrix is in the form of microspheres and/or nanospheres.

An in vivo medical treatment device coated with a pharmaceutically effective amount of an emulsion comprising a biocompatible biodegradable polymer in an amount of about 0.01% to 15% (w/v) and a nucleic acid in an amount of about 0.01% to 10% (w/v) and having a viscosity of about 30 to 50 centipoise.

An in vivo medical treatment device coated with a pharmaceutically effective amount of a suspension comprising about 0.01% to 80% (w/v) microspheres and/or nanospheres and having a viscosity of about 30 to 50 centipoise, wherein the microspheres and/or nanospheres are comprised of a biocompatible biodegradable polymeric core and a nucleic acid in an amount of about 0.01% to 10% (w/w).