Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics

A method for preconditioning an output pattern of a biochip, said method comprising the steps of:

• a) tessellating the output pattern to match characteristics of a predetermined stimulus pattern yielding a tessellated output pattern;
• b) extracting local parametrics from the tessellated output pattern;
• c) determining whether a degree of amplitude wandering representative of the local parametrics is within a predetermined allowable generator function limit;
• and
• d) if not, renormalizing the tessellated output pattern to further match spectral properties of the stimulus pattern and repeat the steps b)-d).

A method for performing a convergent reverberant dynamics resonance analysis of a biochip output pattern to identify mutations represented thereby, said method comprising the steps of:

• a) determining resonance dynamics relaxation values based upon the preconditioned output pattern and the resonance stimulus;
• b) filtering the dynamics relaxation values using ensemble boundary and CSR filters to yield a second set of values;
• c) applying bulk property estimators to the dynamics relaxation values to yield a third set of values;
• d) evaluating the second and third sets of values to determine whether a predetermined degree of resonance convergence has been achieved;
• and
• e) determining whether a paralysis of dynamics has occurred and, if so, repeat steps a)-e).

A system for analyzing an output pattern of a biochip to identify mutations, if any, present in a biological sample applied to the biochip, said system comprising:

• a tesselation unit operative to tessellate the output pattern;
• a stimulus pattern generation unit operative to generate a stimulus pattern associated with the set of known mutations;
• a resonance pattern generation unit operative to generate a resonance pattern representative of resonances between the stimulus pattern and the tessellated output pattern;
• a resonance pattern interpretation unit operative to interpret the resonance pattern to yield a set of confirmed mutations by comparing resonances found therein with predetermined resonances expected for the selected set of mutations.

A system for performing a convergent reverberant dynamics resonance analysis of a biochip output pattern to identify mutations represented thereby, said system comprising:

• a determination unit operative to determine resonance dynamics relaxation values based upon the preconditioned output pattern and the resonance stimulus;
• a fitler operative to filter the dynamics relaxation values using ensemble boundary and CSR filters to yield a second set of values;
• a estimator unit operative to apply bulk property estimators to the dynamics relaxation values to yield a third set of values;
• an evaluation unit operative to evaluate the second and third sets of values to determine whether a predetermined degree of resonance convergence has been achieved;
• and
• a paralysis detection unit operative to detect whether a paralysis of dynamics has occurred.