Antisense transcript expressed in B lymphocytes and synthetic oligonucleotides useful to inhibit the activity thereof
AssigneeConsiglio Nazionale Delle Richerche
InventorsSusanna Morelli, Angelo Nicolin, Alessandro Quattrone
Life of this patent
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Abstract
An antisense transcript which complements the immature mRNA of the IgH gene, originates in the 3' region downstream the enhancer region (E) and terminates in the 5' region upstream the J region. Oligodeoxynucleotides directed to any region of said antisense transcript and their use for diagnostic or pharmaceutical purposes.
Claims29
An oligodeoxynucleotide which is complementary to an antisense transcript of an immature mRNA of the IgH gene, inhibits the activity of said antisense transcripts and has a base sequence consisting of a member selected from the group consisting of
- ACT ACT ACG GTA TGG ACG, (SEQ ID NO:
- 1)
- TCC TCA GGT AAG AAT GGC, (SEQ ID NO:
- 2)
- ACC ATG TTC CGA GGG GAC, (SEQ ID NO:
- 3)
- GAG CCA CAT TTG GAC GAG, (SEQ ID NO:
- 4)
- AGT GAT GGC TGA GGA ATG, (SEQ ID NO:
- 5)
- CTG TCC AAG TAT TTG AAA, (SEQ ID NO:
- 6)
- GGC TGG AAA GAG AAC TGT, (SEQ ID NO:
- 7)
- TCT GAA AGT GAT CTA CTG, (SEQ ID NO:
- 8)
- TTC CGT TTC TAA AAT AAG, and (SEQ ID NO:
- 9)
- GAT GCG TGG CTT CTG CTG (SEQ D NO:
- 10).
An oligodeoxynucleotide, which has a length of 10 to 100 bases and which is complementary to a sequence of an antisense transcript complementing the J6 region of the immature mRNA of the IgH gene, wherein the oligonucleotide inhibits the activity of said antisense transcript.
An oligodeoxynucleotide, which has a length of 10 to 100 bases and which is complementary to a sequence of an antisense transcript complementing the J6/E region of an immature mRNA of the IgH gene, wherein the oligonucleotide inhibits the activity of said antisense transcript.
An oligodeoxynucleotide, which has a length of 10 to 100 bases and which is complementary to a sequence of an antisense transcript complementing the E region of an immature mRNA of the IgH gene, wherein the oligonucleotide inhibits the activity of said antisense transcript.
Dependencies are inferred from the claim text.