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AssigneesThe Regents of the University of California, Rutgers, The University of New Jersey
InventorsGeorge L. Kenyon, Margaret Stauber, Karl Maurer, Dolan Eargle, Angelika Muscate, Andrew Leavitt, Diana C. Roe, Todd J. A. Ewing, Allan G. Skillman, Jr., Edward Arnold, Irwin D. Kuntz, Malin Young
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The present invention relates to a novel class of compounds that are potent inhibitors of HIV reverse transcriptase and HIV integrase. In addition to being multienzyme inhibitors, the inventive compounds of the present invention are remarkable in at least two other respects. First, they do not appear to be toxic to cells at typical therapeutic concentrations. Second, they appear to be equally effective against mutant strains of HIV reverse transcriptase commonly found in patients who have developed resistance to current reverse transcriptase inhibitors. Because the inventive compounds show promise in combatting viral resistance and are potent inhibitors of both HIV reverse transcriptase and integrase, they are ideal candidates for use in combination with existing therapies or alone in treating AIDS or HIV infection.
A method for treating a retroviral infection in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a naphthol compound, or a pharmaceutically acceptable salt thereof, having the structure:
A method for treating a retroviral infection in a patient in need thereof comprising:
A method for treating a retroviral infection in a patient in need thereof comprising:
A method for treating a retroviral infection in a patient in need thereof comprising:
A compound having the structure where P is one or more counterions.
A compound having the structure ##STR213## where P is one or more counterions.
A compound having the structure ##STR214## where P is one or more counterions.
A compound having the structure ##STR215## where P is one or more counterions.
A compound having the structure ##STR216## where P is one or more counterions.
A compound having the structure ##STR217## where P is one or more counterions.
A compound having the structure ##STR218## where P is one or more counterions.
A compound having the structure ##STR219## where P is one or more counterions.
Dependencies are inferred from the claim text.