US 6,140,361 A · Use of 2-deoxystreptamine as a molecular scaffold for the preparation of functionally and spatially diverse molecules and pharmaceutical compositions thereof

Abstract

2-Deoxystreptamine is an aminocyclitol whose structural stability and abundant functionality make it an attractive scaffold for the combinatorial generation of small molecules. The ability to selectively functionalize the various positions of 2-deoxystreptamine with an almost infinite number of different groups ensures that the libraries so generated will be both spatially and functionally diverse. These compounds can then be screened for biological activity to afford lead compounds for pharmaceutical programs. Additionally, biological ligand mimics based on 2-deoxystreptamine can be readily appended, either directly or through a tether, to solid surfaces or incorporated covalently into gels to afford novel materials useful in separation science.

Claims8

Dependent claims

A compound having the structure:

##STR43## wherein R.sup.A and R.sup.B are independently hydrogen, alkyl, perfluoroalkyl, phenylmethyl, nitrophenylmethyl, (aminoimido)phenylmethyl, (alkylaminoimido)phenylmethyl, (acylaminoimido)phenylmethyl, acyl, aroyl, heteroaroyl, amino, alkylamino, arylamino, heteroarylamino, acylamino, aroylamino, heteroaroylamino, alkyloxycarbonylamino, aryloxycarbonylamino or heteroaryloxycarbonylamino;
and wherein R.sub.1 and R.sub.3 are independently alkyl, aryl, heteroaryl, acyl, heteroaroyl or aroyl and R.sub.2 is hydrogen.

Dependencies are inferred from the claim text.

Facts

Application

09/273,964Filed 22 Mar 1999 · division

Priority

6 Sep 1996

Granted

31 Oct 2000

Term ends

Not estimatedThe source records don’t support an estimate.

Classification26 codes

C07D 207/32
Having two double bonds between ring members or between ring members and non-ring members: with only hydrogen atoms, hydrocarbon or substituted…
A61P 31/00
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/18
For RNA viruses: for HIV
C07C 215/44
Having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton: bound to…

Use of 2-deoxystreptamine as a molecular scaffold for the preparation of functionally and spatially diverse molecules and pharmaceutical compositions thereof

Life of this patent

Use of 2-deoxystreptamine as a molecular scaffold for the preparation of functionally and spatially diverse molecules and pharmaceutical compositions thereof

Life of this patent

Abstract

Claims8