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US 6,140,114 AGranted
Defective viral vaccine particles obtained in vivo or ex vivo
AssigneeUniversite Pierre et Marie Curie (Paris VI)
InventorsDavid Klatzmann, Jean-Loup Salzmann
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Abstract
The present invention relates to a vaccine consisting of defective viral particles as are obtained in vivo or ex vivo, in individuals infected or capable of being infected with a virus, after expression of the genes carried by a vector or a combination of vectors and comprising at least the structural genes necessary for the constitution of the viral particle.
Claims24
A vaccine comprising a vector wherein said vector comprises:
- (a) a gag gene and a pol gene of a retrovirus under the control of a first promoter wherein said first promoter is different from the promoter of said retrovirus;
- (b) a first polyadenylation signal which is different from the long terminal repeat of said retrovirus and is 3' from said gag gene and pol gene;
- (c) an env gene of a retrovirus under the control of a second promoter wherein said second promoter is different from the promoter of said retrovirus;
- and
- (d) a second polyadenylation signal which is different from the long terminal repeat of said retrovirus;
- and is 3' from said env gene.
3 more elements
A vaccine comprising:
- a vector wherein said vector comprises:
- (a) a defective retroviral genome comprising the long terminal repeat sequences, a gag gene and a pol gene of a retrovirus;
- (b) an env gene of a retrovirus under the control of:
- (i) a promoter wherein said promoter is different from the promoter of said virus;
- and
- (ii) a polyadenylation signal which is different from the long terminal repeat of said virus and is 3' from said env gene.
3 more elements
A vaccine comprising:
- a vector wherein said vector comprises:
- (a) an attenuated retroviral genome lacking a .psi. sequence comprising:
- (i) a 5' long terminal repeat sequence;
- (ii) a gag gene;
- (iii) a mutated reverse transcriptase or an integrase gene;
- (iv) an env gene;
- and
- (v) a polyadenylation signal which is different from the long terminal repeat of said virus and is 3' from said env gene.
5 more elements
A vaccinal vector comprising:
- (a) a defective retroviral genome comprising long terminal repeat sequences, a gag gene and a pol gene of a retrovirus and lacking a Psi sequence;
- (b) an env gene of a retrovirus under the control of a promoter wherein said promoter is different from the promoter of said virus;
- and
- (c) a polyadenylation signal which is different from the long terminal repeat of said retrovirus and is 3' from said env gene.
1 more element
Dependencies are inferred from the claim text.