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US 6,139,870 AGranted
Stabilized nanoparticles which are filterable under sterile conditions
AssigneeAventis Pharma S.A.
InventorThierry Verrecchia
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Abstract
Stabilized nanoparticles capable of being filtered under sterile conditions and including at least one hydrophobic, water-insoluble and non-water-dispersible polymer or copolymer (and optionally an active principle) emulsified in a solution of phospholipids and an oleic acid salt.
Claims21
A stable nanoparticle suspension comprising at least one hydrophobic, water-insoluble and water indispersible polymer or copolymer emulsified in an aqueous phase comprising a phospholipid and an oleic acid salt.
A process for the preparation of nanoparticles which comprises:
- (a) preparing an aqueous dispersion or solution of at least one phospholipid and at least one oleic acid salt;
- (b) adding thereto an organic phase comprising a hydrophobic, water-insoluble and water-indispersible polymer or copolymer and an organic solvent;
- (c) homogenizing the resulting mixture;
- (d) removing the organic solvent;
- and
- (e) filtering the resulting suspension.
3 more elements
Dependencies are inferred from the claim text.