Antisense inhibition of methionine aminopeptidase 2 expression
AssigneeIsis Pharmaceuticals, Inc.
InventorsBrett P. Monia, Jacqueline Wyatt
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of methionine aminopeptidase 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding methionine aminopeptidase 2. Methods of using these compounds for modulation of methionine aminopeptidase 2 expression and for treatment of diseases associated with expression of methionine aminopeptidase 2 are provided.
Claims23
An antisense compound 8 to 30 nucleobases in length targeted to a start codon, nucleobases 1513-1884 of a 3'-untranslated region, or nucleobases 69-1414 of a coding region of human methionine aminopeptidase 2 (SEQ ID NO:3), wherein said antisense compound specifically hybridizes with and inhibits the expression of human methionine aminopeptidase 2.
The antisense compound of 2 wherein the antisense oligonucleotide is a chimeric oligonucleotide.
An antisense compound up to 30 nucleobases in length comprising at least an 8-nucleobase portion of SEQ ID NO:
- 10, 11, 12, 13, 14, 15, 16, 17, 20, 21, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 49, 50, 51, 52, 54, 55, 56, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86 or 87 which inhibits the expression of human methionine aminopeptidase 2.
Dependencies are inferred from the claim text.