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US 6,136,562 AGranted
Bovine placental lactogen
AssigneeMonsanto Company
InventorsJohn C. Byatt, Scott D. Hauser, Gwen G. Krivi, Ned R. Siegel, Christine E. Smith, Jeannine M. Stafford
Life of this patent
Estimating the term…
Abstract
This invention relates to bovine placental lactogen, amino acid sequences thereof, DNA sequences coding therefor, its production by synthetic means and its use to produce a biological response in cattle.
Claims26
A synthetic DNA molecule comprising a DNA sequence encoding a peptide having the following amino acid sequence, reading from the amino terminus to the carboxy terminus:
- X-Glu-Asp-Tyr-Ala-Pro-Tyr-Cys-Lys-Asn-Gln-Pro-Gly-Asn-Cys-Arg-Ile-Pro-Leu-G ln-Ser-Leu-Phe-Glu-Arg-Ala-Thr-Leu-Val-Ala-Ser-Asn-Asn-Tyr-Arg-Leu-Ala-Arg- Glu-Met-Phe-Asn-Glu-Phe-Asn-Lys-Gln-Phe-Gly-Glu-Gly-Lys-Asn-Phe-Thr-Ser-Lys -Val-Ile-Asn-Ser-Cys-His-Thr-Glu-Phe-Met-Thr-Thr-Pro-Asn-Asn-Lys-Glu-Ala-Al a-Ala-Asn-Thr-Glu-Asp-Glu-Ala-Leu-Leu-Arg-Leu-Val-Ile-Ser-Leu-Leu-His-Ser-T rp-Asp-Glu-Pro-Leu-His-Gln-Ala-Val-Thr-Glu-Leu-Leu-His-Arg-Asn-Gly-Ala-Ser- Pro-Asp-Ile-Leu-Ala-Arg-Ala-Lys-Glu-Ile-Glu-Asp-Lys-Thr-Lys-Val-Leu-Leu-Glu -Gly-Val-Glu-Met-Ile-Gln-Lys-Arg-Val-His-Pro-Gly-Glu-Lys-Lys-Asn-Glu-Pro-Ty r-Pro-Val-Trp-Ser-Glu-Lys-Ser-Ser-Leu-Thr-Ala-Asp-Asp-Glu-Asp-Val-Arg-Gln-T hr-Ala-Phe-Tyr-Arg-Met-Phe-His-Cys-Leu-His-Arg-Asp-Ser-Ser-Lys-Ile-Ser-Thr- Tyr-Ile-Asn-Leu-Leu-Lys-Cys-Arg-Phe-Thr-Pro-Cys;
- wherein X is Ala, Val, Met-Ala or Met-Val.
A synthetic DNA molecule comprising a DNA sequence coding for a peptide having the following amino acid sequence, reading from the amino terminus to the carboxy terminus:
- Met-Ala-Pro-Ala-Ser-Ser-His-Arg-Gly-His-Gln-Trp-Ile-Cys-Asp-Leu-Val-Arg-Gly -Ser-Cys-Leu-Leu-Leu-Leu-Leu-Val-Val-Ser-Asn-Leu-Leu-Leu-Cys-Gln-Gly-X-Glu- Asp-Tyr-Ala-Pro-Tyr-Cys-Lys-Asn-Gln-Pro-Gly-Asn-Cys-Arg-Ile-Pro-Leu-Gln-Ser -Leu-Phe-Glu-Arg-Ala-Thr-Leu-Val-Ala-Ser-Asn-Asn-Tyr-Arg-Leu-Ala-Arg-Glu-Me t-Phe-Asn-Glu-Phe-Asn-Lys-Gln-Phe-Gly-Glu-Gly-Lys-Asn-Phe-Thr-Ser-Lys-Val-I le-Asn-Ser-Cys-His-Thr-Glu-Phe-Met-Thr-Thr-Pro-Asn-Asn-Lys-Glu-Ala-Ala-Ala- Asn-Thr-Glu-Asp-Glu-Ala-Leu-Leu-Arg-Leu-Val-Ile-Ser-Leu-Leu-His-Ser-Trp-Asp -Glu-Pro-Leu-His-Gln-Ala-Val-Thr-Glu-Leu-Leu-His-Arg-Asn-Gly-Ala-Ser-Pro-As p-Ile-Leu-Ala-Arg-Ala-Lys-Glu-Ile-Glu-Asp-Lys-Thr-Lys-Val-Leu-Leu-Glu-Gly-V al-Glu-Met-Ile-Gln-Lys-Arg-Val-His-Pro-Gly-Glu-Lys-Lys-Asn-Glu-Pro-Tyr-Pro- Val-Trp-Ser-Glu-Lys-Ser-Ser-Leu-Thr-Ala-Asp-Asp-Glu-Asp-Val-Arg-Gln-Thr-Ala -Phe-Tyr-Arg-Met-Phe-His-Cys-Leu-His-Arg-Asp-Ser-Ser-Lys-Ile-Ser-Thr-Tyr-Il e-Asn-Leu-Leu-Lys-Cys-Arg-Phe-Thr-Pro-Cys;
- wherein X is either Ala or Val.
Dependencies are inferred from the claim text.