Methods and compositions for reducing or eliminating post-surgical adhesion formation
AssigneeLife Medical Sciences, Inc.
InventorsDaniel Cohn, Eli Pines, Anna Hotovely
Life of this patent
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Abstract
The present invention relates to a method for reducing adhesions associated with post-operative surgery. The present method comprises administering or affixing a polymeric composition preferably comprising chain extended, coupled or crosslinked polyester/poly(oxyalkylene) ABA triblocks or AB diblocks having favorable EO/LA ratios to a site in the body which has been subjected to trauma, e.g. by surgery, excision or inflammatory disease. In the present invention, the polymeric material provides a barrier to prevent or reduce the extent of adhesions forming.
Claims89
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a prepolymerized polymeric composition comprising chain extended, coupled or crosslinked poly(ester)/poly(oxyalkylene) ABA triblocks or AB diblocks, where A is a polyester unit and B is a polyoxyalkylene polymer unit, said polymeric composition having an EO/LA ratio falling within the range of about 0.1 to about 100.
A method for reducing or preventing adhesions in a patient comprising exposing tissue which has been subjected to tissue damage and is at risk for the formation of adhesions to a polymeric composition comprising polymers of the chemical structure:
- ##STR17## where m, a and b are positive integers, R is an ethylene group and/or propylene group with the proviso that R is not exclusively a propylene group when R' contains an absence of poly(ethylene oxide), R' is a C.sub.2 to C.sub.12 alkylene group, a cycloalkyl or cycloalkyl-containing group, an aryl or aryl-containing group, 4,4'-diphenylmethane, toluene, naphthalene, 4,4'-dicyclohexylmethane, cyclohexyl, 3,3'-dimethylphenyl, 3,3'-dimethyl-diphenylmethane, 4,6'-xylylene, 3,5,5-trimethylcyclohexyl, 2,2,4-trimethylhexamethylene, p-phenylene, or a poly(ethylene oxide) containing or poly(ethylene oxide) rich chain and R.sub.1 is H or CH.sub.3.
Dependencies are inferred from the claim text.