Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors
AssigneeBoard of Regents, The University of Texas System
InventorsChandrasekhar Yallampalli, Sunil J. Wimalawansa
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Abstract
Primary and secondary osteoporosis in a female or a male mammal is treated by administering thereto a nitric oxide synthase substrate, a nitric oxide donor or both, optionally; in further combination with one or more of an estrogen, a progestin, an anabolic steroid. Nitric oxide substrate or donor also can be combined with one or more of other medications acting on bone, such as bisphosphonate, calcitonin, fluoride, androgen and other novel therapeutic agents. Either nitric oxide donor or substrate by itself or combination with other medications as described above can be used in both women and men, (preferably human) for prevention and treatment of osteoporosis and other metabolic bone disorders.
Claims98
A method for prevention or treatment of primary and secondary osteoporosis of a female or male mammal comprising administering to the susceptible or afflicted mammal at least one of L-arginine effective to raise the blood level of circulating L-arginine to at least about 1 mM above the normally circulating levels or a nitric oxide donor in an amount producing a level of nitric oxide about equivalent to that produced by the elevated L-arginine levels.
A pharmaceutical composition comprising (a) at least one of L-arginine and a nitric oxide donor, and (b) at least one of, an estrogen, a progestin, a calcitonin, a fluoride, an anabolic steroid, or an androgen.
A method for prevention or treatment of primary and secondary osteoporosis comprising administering a nitric oxide donor in an amount effective to provide a level of nitric oxide donor of about 1-1000 nM to a female or male mammal susceptible to or suffering from primary or secondary osteoporosis.
A pharmaceutical composition comprising a nitric oxide donor and at least one compound selected from the group consisting of an estrogen, a progestin, a calcitonin, a fluoride, an anabolic steroid, and an androgen.
Dependencies are inferred from the claim text.