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US 6,132,765 AGranted
Drug delivery via therapeutic hydrogels
AssigneeUroteq Inc.
InventorsFrank DiCosmo, Valerio DiTizio
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.
Claims18
A medical device comprising:
- a. a polymeric liquid conduit having an external surface;
- b. a gelatin hydrogel matrix material;
- and
- c. a therapeutic agent encapsulated in a liposome and confined within said matrix material,
- wherein said matrix material is affixed to the external surface of said polymeric liquid conduit by a plurality of covalent bonds.
2 more elements
A medical device comprising:
- a. a silicone rubber liquid conduit having an external surface;
- b. a bifunctional linker molecule comprising a fluorinated aroyl azido group convalently bound to said external surface of said liquid conduit;
- c. a layer of polyethylene glycol-gelatin matrix material affixed to the external surface of said liquid conduit by a covalent bond between an amine functionality of said gelatin and said bifunctional linker molecule;
- and
- d. ciprofloxacin encapsulated in a liposome and dispersed throughout said matrix material.
2 more elements
A medical device comprising:
- a. a polymeric liquid conduit having an external surface:
- b. a layer of a gelatin hydrogel matrix material having a plurality of covalent bonds between a surface of the layer of hydrogel matrix material and the external surface of the liquid conduit;
- and
- c. a therapeutic agent encapsulated in a liposome and confined within said layer of said matrix material.
1 more element
Dependencies are inferred from the claim text.