Cloning of mite allergens
AssigneeImmuLogic Pharmaceuticals, Inc.
InventorsWayne Robert Thomas, Geoffrey Alexander Stewart, Keven Turner, Richard John Simpson
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Abstract
Isolated peptides comprising at least one epitope, such as a T or B cell epitope, of the Group II proteine allergen from Dermatophagoides, Der p II, are disclosed. Also disclosed are therapeutic compositions containing one or more such peptides, and therapeutic methods of using such peptides. Also disclosed are diagnostic compositions containg one or more such peptides, and dianostic methods of using such peptides.
Claims12
An isolated peptide from a Der p II protein allergen having the amino acid sequence shown in FIG. 7, wherein said peptide comprises at least one epitope of said Der p II protein allergen but does not comprise the entire amino acid sequence shown in FIG. 7.
An isolated peptide comprising at least one epitope of a Der p II protein allergen, wherein said peptide is encoded by a nucleotide sequence which hybridizes under high stringency conditions to a portion of the nucleotide sequence shown in FIG. 7 or the complementary nucletide sequence, and wherein said high stringency conditions comprise hybridization at Tm-20 followed by at least one post-hybridization wash at Tm-12.
Dependencies are inferred from the claim text.